Primary “drug modulated/modulating” genes (large blue circles) and their extended common interactors (small red circles).

<p>‘+’ on each gene (node) indicates that the gene’s linkages are suppressed and ‘−’ indicates all linkages of the gene have been shown. The different coloured interaction between genes represents various biological processes that identified the interactions. Every line (edge) connecting each gene pair represents an interaction. The colour of the line specifies the experimental method used to identify that interaction. For example, “black” coloured line connecting genes <i>ITGAV</i> and <i>FN</i> represents the <i>transcriptional upregulation</i> method. If an interaction is identified by several different biological methods, then the line will be coloured in segments with corresponding colours for each methods. For example 5 different colours indicated in line connecting genes <i>ITGAV</i> and <i>ITGB1</i> represent 5 biological methods used for identification of this interaction i.e. <i>in vivo, inferred by curator, affinity chromatography, co- immunoprecipitation</i> and <i>pull down</i> method.